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Abstract #55542 Published in IGR 15-4
Initial central scotomas vs peripheral scotomas in normal-tension glaucoma: clinical characteristics and progression rates
Cho HK; Lee J; Lee M; Kee CEye 2014; 28: 303-311
PURPOSE: To investigate clinical characteristics and progression rates of the initial central scotomas (ICS) compared with the initial peripheral scotomas (IPS) in normal-tension glaucoma (NTG) patients. METHODS: Among NTG patients showing a single hemifield defect and who performed more than five reliable standard visual field (VF) tests, medical records of ICS (involvement of ≥3 adjacent points with P<5% within the central 12° of fixation and one point with a P<0.01 within the central 6° of fixation) (n=32) or IPS (no VF abnormality within the central 6° of fixation) (n=34) were retrospectively analyzed. The changes of mean thresholds from 10 zones of the glaucoma hemifield test, central 6° and 12° zones, peripheral zones other than central 6° and 12°, and the entire hemifield were inspected. To calculate the progression rates, linear mixed-effect model was employed. RESULTS: There were no significant differences between the two groups in age, gender, ocular factors including baseline/mean treated intraocular pressure, and systemic factors including systolic or diastolic blood pressure/perfusion pressure, mean ocular perfusion pressure (all P>0.05). There were no significant differences in baseline mean deviation and pattern standard deviation (P>0.05) between the two groups, but VF index was significantly lower in ICS group than in IPS group (P=0.001). The progression rates between the two groups were not significantly different in all zones we investigated (all P>0.05). CONCLUSIONS: Newly diagnosed cases of NTG with ICS may not differ from those with IPS in clinical characteristics and progression rates under treatment.
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Classification:
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
6.6.2 Automated (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)
