advertisement
Abstract #5558 Published in IGR 2-1
Perspectives on glaucoma genetics and the trabecular meshwork glucocorticoid response gene
Polansky JROphthalmology Clinics of North America 2000; 13:111-121
Work currently being done in the field of glaucoma genetics is providing new diagnostic and potentially therapeutic opportunities. Using the recent findings on the trabecular meshwork glucocorticoid response (TIGR) gene as a paradigm, we may learn of mechanisms that, by way of environmental influences and 'susceptibility' or 'protective' genes, can modulate disease phenotype by way of the gene's promoter. The value of genetic testing in glaucoma and the research opportunities derived from the studies should continue, aiding the clinician in providing new approaches for defining and treating different forms of glaucoma. This article discusses the background of the TIGR gene, its clinical implications, and new research applications.
Dr. J.R. Polansky, Department of Ophthalmology, UCSF Medical Center, 10 Kirkham Street, San Francisco, CA 94143-0730, USA
Classification:
1.2 Population genetics (Part of: 1 General aspects)
