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Abstract #55593 Published in IGR 15-4

Apoptosis in the iris and trabecular meshwork of medically treated and untreated primary open angle glaucoma patients

Aktas Z; Karaca EE; Gonul II; Hasanreisoglu M; Onol M
International Journal of Ophthalmology 2013; 6: 827-830

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AIM: To compare the trabecular meshwork (TM) and iris apoptosis of treated and untreated primary open angle glaucoma (POAG) patients. METHODS: Eight treatment-naive, newly diagnosed (group 1) and 11 medicaly treated (group 2) patients with POAG were included in the study. Each patient underwent a limbus-based trabeculectomy. The TM and peripheral iris specimens were dissected out and were snap-frozen in liquid nitrogen and stored at -80°C until they were assayed. Apoptosis in each group was assesed by TUNEL method. RESULTS: The mean patient age was 60.6±5.8 years (53-68 years) vs 58.9±8.9 years (47-70 years) in group 1 and group 2 (P=0.859). The mean treatment time in group 2 was 22.2±7.3 months (12-34 months). Apoptotic indexes in TM and iris were significantly higher in POAG patients using medication (group 2) compared to treatment-naive POAG patients (group 1) (P=0.004, 0.015; respectively). CONCLUSION: Long term administration of topical antiglaucoma medications causes additional toxic effects on TM.

Full article

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Classification:

2.5.1 Trabecular meshwork (Part of: 2 Anatomical structures in glaucoma > 2.5 Meshwork)
2.8 Iris (Part of: 2 Anatomical structures in glaucoma)

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