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Abstract #5567 Published in IGR 2-1

Cathepsin A activity in the vitreous body of patients with absolute glaucoma and intraocular tumors

Obuchowska I; Stankiewicz A; Bankowski E
Klinika Oczna 1999; 101:167-168


PURPOSE: To evaluate cathepsin A activity in the vitreous body of patients with absolute glaucoma and intraocular tumors. MATERIAL AND METHODS: The studies were performed on human vitreous body taken from eye balls which were enucleated because of absolute glaucoma (18 eyes) and intraocular tumors (14 eyes). Cathepsin A activity was determined by the ninhydrin method with synthetic substrate (N-Cbz-Phe-Ala) at its optimum pH 5.0. RESULTS: Cathepsin A activity in the human vitreous body in absolute glaucoma was twice as high as in intraocular tumors. CONCLUSION: These results suggest that cathepsin A may participate in the pathogenesis of absolute glaucoma and that proteolysis may play a significant role in local destruction of the retina and the optic nerve. LA: Polish

Dr. I. Obuchowska, Katedry i Kliniki Okulistyki AM w Bialymstoku


Classification:

1.3 Pathogenesis (Part of: 1 General aspects)



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