advertisement
Abstract #5609 Published in IGR 2-1
The retinal nerve fiber layer thickness in ocular hypertensive, normal, and glaucomatous eyes with optical coherence tomography
Bowd C; Weinreb RN; Williams JM; Zangwill LMArchives of Ophthalmology 2000; 118:22-26
OBJECTIVES: To quantitatively assess and compare the thickness of the retinal nerve fiber layer (RNFL) in ocular hypertensive eyes with normal and glaucomatous eyes using the Optical Coherence Tomograph (OCT 2000, software version A4X1; Humphrey Instruments, San Leandro, CA). METHODS: The mean RNFL thickness of ocular hypertensive (n=28) eyes was compared with age-matched normal (n=30) and glaucomatous (n=29) eyes. Subject eyes were classified into diagnostic groups based on intraocular pressure, stereoscopic disc photographs, and standard automated perimetry. Three circular scans were obtained for each eye at a diameter of 3.4 mm around the optic disc. In each eye, average RNFL thickness measurements were obtained in temporal, superior, nasal, and inferior quadrants. A single index of average RNFL thickness throughout 360° also was obtained. RESULTS: Mean (95% confidence interval) RNFL was significantly thinner in ocular hypertensive eyes than in normal eyes, 72.8 μm (66.4-78.1 μm) and 85.8 μm (80.2-91.7 μm), respectively. More specifically, RNFL was significantly thinner in ocular hypertensive eyes than in normal eyes in the inferior quadrant, 84.8 μm (75.6-94.0 μm) versus 107.6 μm (99.3-115.9 μm); and in the nasal quadrant, 44.1 μm (37.5-51.7 μm) versus 61.8 μm (53.0-65.6 μm). Retinal nerve fiber layer was significantly thinner in glaucomatous eyes than in ocular hypertensive and normal eyes throughout 360° and in all quadrants. CONCLUSION: These findings suggest that quantitative differences in RNFL thickness exist between age-matched ocular hypertensive, normal, and glaucomatous eyes.
Dr. C. Bowd, Glaucoma Center, Department of Ophthalmology, University of California San Diego, La Jolla, CA 92093-0946, USA
Classification:
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
6.9.2 Optical coherence tomography (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis)
