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Abstract #56266 Published in IGR 16-1
Is utility-based quality of life in adults affected by glaucoma?
Gothwal VK; Bagga DK; Rao HL; Bharani S; Sumalini R; Garudadri CS; Senthil S; Reddy SP; Pathak-Ray V; Mandal AKInvestigative Ophthalmology and Visual Science 2014; 55: 1361-1369
PURPOSE: We evaluated the utility values (UVs), using the time trade off (TTO) technique, associated with primary glaucoma and varying degrees of visual field (VF) loss. METHODS: In this cross-sectional study, 198 adults (mean age, 59.8 years) with primary glaucoma were recruited from the glaucoma clinic of a tertiary center in Hyderabad, South India. Each patient underwent comprehensive glaucoma evaluation, and completed the utility (TTO) and Glaucoma Quality of Life-15 questionnaires (Rasch version, Glaucoma Activity Limitation [GAL]-10). Better mean deviation (MD, using Humphrey Field Analyzer program 24-2) between two eyes was used to classify participants into mild, moderate, and severe VF loss groups. Utilities (range, 0.0-1.0) derived by TTO technique (lifetime traded against perfect vision) and interval level Rasch scores of GAL-10 were used for analyses. RESULTS: Mean UV was 0.81 (95% confidence interval [CI], 0.78-0.84); that is, a decrease in quality of life (QoL) of 19%. Of the subjects, 59% were willing to trade lifetime in return of perfect vision; those willing to trade were significantly younger with poorer acuity in the worse-seeing eye. In univariate and multivariate analysis, severe VF loss in the worse eye was associated with lower UV (β = -0.108; 95% CI, -0.201 to -0.014; P = 0.02). CONCLUSIONS: Our results show that primary glaucoma in adults causes substantial decrease in UVs (and QoL thereof), and is highly dependent on the severity of VF loss in the worse eye.
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Classification:
1.4 Quality of life (Part of: 1 General aspects)
