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Abstract #5678 Published in IGR 2-1
Combined effect of topical latanoprost and timolol on retinal blood flow and tissue circulation in the optic nerve head in cynomolgus monkeys
Ishii K; Araie MNippon Ganka Gakkai Zasshi 2000; 104: 3-10
PURPOSE: To evaluate the combined effect of topical latanoprost and timolol on the retinal blood flow and the tissue circulation of the optic nerve head (ONH) in cynomolgus monkeys. MATERIALS AND METHODS: 30 ml of latanoprost (0.005%) was instilled once daily and timolol (0.5%) twice daily into one eye, and physiological saline as a control into the other eye of eight cynomolgus monkeys for six days. Blood velocity through the retinal veins was measured using a KOWA laser speckle blood flow Meter. The ONH tissue blood velocity normalized blur (NBONH) was measured using a laser speckle tissue circulation analyzer. Retinal blood flow, NBONH, intraocular pressure (IOP), blood pressure, and pulse rate were measured before the first instillation, four hours after the first instillation on the second experimental day, and four hours after the last instillation. RESULTS: After the first instillation on the second experimental day, the retinal blood flow was decreased to below the baseline, but six-day instillation caused no significant change from the baseline. Six-day instillation increased the NBONH in the treated eyes by 10% from the baseline and by 7% from that in the fellow control eye. After the six-day instillation, the IOP was lowered by 7.8±2.7 (mean ± standard deviation) mmHg and 3.6±4.3 mmHg in the treated and control eyes, respectively. CONCLUSIONS: The results suggest that six-day instillation of latanoprost once daily and timolol twice daily has no significant effect on the retinal blood flow, and significantly increases the ONH tissue blood velocity in monkey eyes. LA: Japanese
Dr. K. Ishii, Eye Clinic, Omiya Red Cross Hospital, Yono, Japan
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
11.4 Prostaglandins (Part of: 11 Medical treatment)
