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Abstract #5679 Published in IGR 2-1
Doppler-sonography of the short posterior ciliary arteries in primary open angle glaucoma patients
Klingmuller V; Schmidt K-G; Ruckmann AV; Koch B; Stein AUltraschall in der Medizin 2000; 21:32-37
AIM: The area of primary damage in glaucomas is the optic nerve head. This region is directly supplied by the peripapillary choroid and the short posterior ciliary arteries (SPCA). This study was designed to evaluate the choroidal and SPCA hemodynamics in high tension (HTG) and normal tension (NTG) primary open-angle glaucoma patients, as well as in healthy controls (CTL). METHODS: Twenty HTG, 12 NTG, and 32 age-matched volunteers (CTL) without clinically relevant extracranial stenosis of the carotid arteries were evaluated for ocular pulse amplitude (OPA; OBF-System OBF Labs, UK) and for temporal SPCA peak systolic flow (PSV), enddiastolic flow (EDV), pulsatility (PI) and resistance indices (RI) using a 9 MHz phased array (Elegra Advanced System; Siemens, Germany). RESULTS: (mean ± SD): In the control group the PSV (cm/sec) of the SPCA was 10.90±1.53; EDV (cm/sec) was 3.24±0.24, PI was 1.30±0.39, RI was 0.69±0.11, OPA (mmHg) was 2.2±0.25; IOP (mmHg) was 14.6±1.5. When compared to CTL matched for age, sex, and refraction, NTG patients showed the following RESULTS: OPA was significantly (p < 0.05) reduced, Doppler sonography showed a significant (p < 0.05) reduction in diastolic flow patterns and a significant (p < 0.05) increase in PI and RI. In HTG patients the parameters investigated where not significantly (p>0.05) altered. CONCLUSIONS: These data suggest reduced hemodynamics in the choroid and in the SPCA of NTG patients, which may contribute to progression of the optic neuropathy. In HTG, the Doppler parameters and the OPA are not altered compared to the control group. LA: German
Dr. V. Klingmuller, Abteilung Diagnostische Radiologie, Klinikum Justus-Liebig-Universität, Giessen, Klinikstrasse 29, 35385 Giessen, Germany
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
