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Abstract #5680 Published in IGR 2-1
Long-term effect of topically applied isopropyl unoprostone on microcirculation in the choroid-retina
Makimoto Y; Sugiyama T; Kojima S; Azuma INippon Ganka Gakkai Zasshi 2000; 104: 39-43
PURPOSE: To study the long-term effect of topically applied 0.12% isopropyl unoprostone (unoprostone, Rescula) on microcirculation in the ocular fundus. MATERIALS AND METHODS: Using a laser speckle tissue circulation analyzer, normalized blur (NB), a quantitative index of blood flow velocity and tissue blood flow, was measured in the optic nerve head (ONH) and choroid-retina before and 4.5 hours after an instillation of placebo into both eyes in 11 normal human volunteers. Intraocular pressure (IOP), blood pressure, and pulse rate were also measured. A drop of unoprostone or the placebo was instilled into each eye in a double-blind manner twice a day for 21 days (the treated or untreated eye). RESULTS: Twenty-one days later, NB values in the ONH and the choroid-retina increased significantly and the IOP decreased significantly only in the treated eyes. Ocular perfusion pressure showed no significant changes. CONCLUSIONS: These results suggest that the increase of the blood flow in the microcirculation in the human ocular fundus following the relatively long-term topical application of unoprostone may be due to reduction in vascular resistance. LA: Japanese
Dr. Y. Makimoto, Department of Ophthalmology, Osaka Medical College, Takatsuki, Japan
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
11.4 Prostaglandins (Part of: 11 Medical treatment)
