advertisement
Abstract #5688 Published in IGR 2-1
Anterior chamber depth measurement as a screening tool for primary angle-closure glaucoma in an East Asian population
Devereux JG; Foster PJ; Baasanhu J; Uranchimeg D; Lee PS; Erdenbeleig T; Machin D; Johnson GJ; Alsbirk PHArchives of Ophthalmology 2000; 118:257-263
OBJECTIVES: To evaluate anterior chamber depth measurement as a method of screening for primary angle-closure glaucoma in an East Asian population. DESIGN: A two-phase, cross-sectional, community-based study. SETTING: Rural and urban locations in the Hovsgol and Omnogobi provinces, Mongolia. PARTICIPANTS: Nine hundred and forty-two (94.2%) of 1000 individuals in Hovsgol(1995) and 775 (96.9%) of 1000 individuals in Omnogobi (1997) aged 40 years or older were examined. MAIN OUTCOME MEASURES: Anterior chamber depth was measured by optical pachymetry, slit-lamp-mounted A-mode ultrasound, and hand-held ultrasound. Gonioscopy was used to detect occludable angles, defined as one in which the trabecular meshwork was visible for less than 90° of angle circumference. Primary open-angle glaucoma was diagnosed in subjects with an occludable angle and glaucomatous optic neuropathy with visual morbidity. The area under the curve in a receiver operating characteristic plot was used to compare test performance. RESULTS: Optical pachymetry outperformed the slit-lamp-mounted ultrasound method of anterior chamber depth measurement (area under the curve, 0.93 and 0.90, respectively; z test, p=0.001). Hand-held ultrasound (area under the curve, 0.86) was inferior to optical measurement (z test, p=0.001) but did not differ significantly from slit-lamp ultrasound (z test, p=0.06). The optical method gave sensitivity of 85% and specificity of 84% at a screening cutoff of less than 2.22 mm for detecting occludable angles. CONCLUSIONS: Measurement of axial anterior chamber depth can detect occludable angles in this Asian population and therefore may have a role in population screening for primary angle-closure glaucoma.
Dr. J.G. Devereux, Department of Preventive Ophthalmology, Institute of Ophthalmology, University College London, UK
Classification:
6.12 Ultrasonography and ultrasound biomicroscopy (Part of: 6 Clinical examination methods)
1.6 Prevention and screening (Part of: 1 General aspects)
9.3 Primary angle closure glaucomas (Part of: 9 Clinical forms of glaucomas)
