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Abstract #56892 Published in IGR 16-2
Pattern electroretinograms during the cold pressor test in normals and glaucoma patients
La Mancusa A; Horn FK; Kremers J; Huchzermeyer C; Rudolph M; Jünemann AInvestigative Ophthalmology and Visual Science 2014; 55: 2173-2179
PURPOSE: To examine the influence of the cold pressor test (CPT) on steady-state pattern electroretinograms (PERG) in healthy subjects and glaucoma patients. METHODS: Steady-state PERGs to 7.8 Hz pattern reversal stimuli were recorded in 63 subjects. Fifteen healthy control subjects, 14 patients with ocular hypertension (OHT), and 34 patients with open-angle glaucoma (20 normotensive [NTG] and 14 high tension glaucoma [HTG]) were examined. Steady-state PERG amplitudes and latencies were analyzed at baseline, during cold stimulus using a modified CPT, and during the subsequent recovery phase. Blood pressure and heart rate were simultaneously recorded in 10 normals and 11 glaucoma patients. RESULTS: During the three test conditions (baseline, ice water, and warm water) glaucoma patients (NTG and HTG) showed significantly reduced PERG amplitudes in comparison with control subjects (P < 0.001) and with OHT patients (P < 0.004). Patients with OHT displayed lower PERG amplitudes than control subjects (nonsignificant, with consideration of Bonferroni). Only NTG patients showed a significant effect of the CPT on PERG amplitude (significant decrease during warm water P = 0.02). Latencies shortened significantly during warm-water period after cold stimulus in control subjects (P = 0.05) and in NTG patients (P = 0.02) with a nonsignificant trend of shortened latencies in the OHT (P = 0.06) and HTG groups (P = 0.3). Systolic and diastolic blood pressure increased during cold water (P < 0.001) and decreased during warming-up conditions (P < 0.001). CONCLUSIONS: This study shows that a CPT influences the PERG responses particularly in NTG. (ClinicalTrials.gov number, NCT00494923.).
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Classification:
6.7 Electro-ophthalmodiagnosis (Part of: 6 Clinical examination methods)
6.13 Provocative tests (Part of: 6 Clinical examination methods)
