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Abstract #57046 Published in IGR 16-2
Risk factors for open-angle glaucoma with normal baseline intraocular pressure in a young population: the Korea National Health and Nutrition Examination Survey
Kim MJ; Kim HS; Jeoung JW; Park KHClinical and Experimental Ophthalmology 2014; 42: 825-832
BACKGROUND: To identify risk factors associated with open-angle glaucoma with normal baseline intraocular pressure in a young Korean population. DESIGN: Retrospective, population-based, case-control study. PARTICIPANTS: Between 2009 and 2010, among participants from the Korea National Health and Nutrition Examination Survey (n = 17 901), subjects between 19 and 39 years of age were included. METHODS: Participants had structured interviews systemic and ophthalmic examination. Glaucoma was diagnosed using the International Society of Geographical and Epidemiological Ophthalmology criteria. MAIN OUTCOME MEASURES: The risk factors for open-angle glaucoma with normal baseline intraocular pressure were analyzed using univariate and multivariate comparisons. RESULTS: Eighty open-angle glaucoma with normal baseline intraocular pressure patients and 4015 controls were included. In the univariate analysis, the patient group was more likely to have higher fasting plasma glucose (98.04 ± 33.16 vs. 89.74 ± 12.65, P < 0.001) and higher proportion of fasting capillary glucose ≥200 mg/dL (P < 0.001) than the control. Multivariate analysis found that high myopia (odds ratio, 3.54 [95% confidence interval, 1.34-9.39], P = 0.011), fasting capillary glucose ≥200 mg/dL (odds ratio, 12.65 [95% confidence interval, 2.63-60.94], P = 0.002) and low high-density lipoprotein cholesterol (odds ratio, 0.96 [95% confidence interval, 0.94-0.99], P = 0.015) were associated with an increased risk of having open-angle glaucoma with normal baseline intraocular pressure. CONCLUSIONS: High myopia, fasting capillary glucose level ≥200 mmol/L and high-density lipoprotein cholesterol level were significant risk factors for open-angle glaucoma with normal baseline intraocular pressure in a young Korean population.
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Classification:
9.2.2 Other risk factors for glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
