advertisement
Abstract #5713 Published in IGR 2-1
The effect of mitomycin C trabeculectomy on the progression of visual field defect in normal-tension glaucoma
Hagiwara Y; Yamamoto T; Kitazawa YGraefe's Archive for Clinical and Experimental Ophthalmology 2000; 238: 232-236
BACKGROUND: The authors investigated in a prospective fashion the visual prognosis and complications in normal-tension glaucoma following unilateral trabeculectomy with adjunctive mitomycin C. METHODS: Trabeculectomy with adjunctive mitomycin C was carried out unilaterally in 21 cases of normal-tension glaucoma. Intraocular pressure (IOP), visual prognosis, and complications were compared between the operated eyes and the non-operated fellow eyes. The follow-up period ranged from two to seven years. RESULTS: The IOP dropped significantly from 14.8±1.8 mmHg (mean ± SD) to 9.6±3.9 mmHg in the operated eyes (p=0.0002, Wilcoxon signed-rank test), but did not drop in the non-operated eyes. The mean deviation (MD) was -12.69±6.41 dB preoperatively and -14.70±5.49 dB at the last clinic visit in the operated eyes, whereas in non-operated eyes it was -7.85±5.65 dB and -11.15±5.62 dB, respectively. The MD deteriorated significantly in both operated and non-operated eyes (operated eyes p=0.0239; non-operated eyes: p=0.0002; Wilcoxon signed-rank test). The MD slope was -0.37±0.60 dB/year and -0.71±0.89 dB/year for the operated and non-operated eyes, respectively (p=0.5243, Mann-Whitney U-test). Visual field deterioration was more frequently observed in the non-operated eyes by a pointwise definition of the progression (p<0.05, McNemar test). Visual acuity deteriorated in six of the operated eyes and in five of the non-operated eyes. Cataract developed in six (29%) of the 21 operated eyes, while of the non-operated eyes, four (19%) developed cataract. CONCLUSIONS: Mitomycin C trabeculectomy is effective in delaying progression of visual field defect in normal-tension glaucoma, but complications may arise and cause some visual disturbance.
Dr. T. Yamamoto, Department of Ophthalmology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu-shi 500-8705, Japan
Classification:
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)