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Abstract #57146 Published in IGR 16-2
Intracameral triamcinolone acetonide in glaucoma surgery: a prospective randomized controlled trial
Koval MS; Moster MR; Freidl KB; Waisbourd M; Jain SG; Ichhpujani P; Myers JS; Pro MJAmerican Journal of Ophthalmology 2014; 158: 395-401.e2
PURPOSE: To evaluate the efficacy and safety of intracameral triamcinolone acetonide (TA) in glaucoma surgery. DESIGN: Prospective randomized clinical trial. METHODS: setting: Institutional-Wills Eye Hospital. study population: Patients undergoing trabeculectomy (with or without cataract surgery) or tube shunt surgery. intervention: Patients were randomized to receive intracameral TA or balanced salt solution at the end of surgery. Follow-up time was 6 months. main outcome measures: Intraocular pressure, visual acuity, inflammation measured by slit-lamp examination and laser flare meter, cataract grading, bleb appearance, dry eye scores, use of supplemental medical therapy, surgical success, and rate of complications. RESULTS: Seventy-seven patients were enrolled in the study, including 37 in the TA group and 40 in the control group. There were no significant differences in success rates between the 2 groups (P = .60). Intraocular pressure and medication use were similar between the groups for each follow-up visit. Dry eye scores were lower in the TA group at month 1 (P = .042), while flare scores were higher in the TA group on day 1 (P = .015) but lower at month 1 (P = .044). The complication rates were higher in the TA group on day 1 (P = .04). All other outcome measures were similar for both groups. CONCLUSIONS: Intracameral TA did not affect the success rates or change the complication rates of glaucoma surgery.
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Classification:
11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)
12.20 Other (Part of: 12 Surgical treatment)
9.4.1 Steroid-induced glaucoma (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
