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Abstract #5720 Published in IGR 2-1
Uveal effusion syndrome: clinical features, surgical treatment, histologic examination of the sclera, and pathophysiology
Uyama M; Takahashi K; Kozaki J; Tagami N; Takada Y; Ohkuma H; Matsunaga H; Kimoto T; Nishimura TOphthalmology 2000; 107:441-449
PURPOSE: To clarify clinical features and pathophysiology and to evaluate surgical outcome of subscleral sclerectomy for primary uveal effusion syndrome. DESIGN: A prospective, consecutive noncomparative case series. PARTICIPANTS: Nineteen eyes of 16 patients diagnosed with uveal effusion syndrome treated at the authors' clinic between 1989 and 1998. METHODS: Patients were examined by routine ophthalmological examinations, fluorescein and indocyanine green angiography; measurement of the axial length of the eyeball; magnetic resonance imaging; and echography. Subscleral sclerectomy (sclerectomy under the scleral flap) was performed at the equator in all patients. Histological examination of excised sclera was carried out on all samples. Patients were followed for outcome over time. MAIN OUTCOME MEASURES: Reattachment of the choroid and retina with resolution of the serous fluid. RESULTS: Three subgroups were identified: In type 1, nanophthalmic eye; the eyeball is small (average axial length 16 mm) and high hypermetropic (average +16 diopters); in type 2, the eyeball size is normal (average axial length 21 mm) with small refractive error; and in type 3, the eyeball size is normal. Histologically, types 1 and 2 demonstrated abnormal sclera with disorganization of collagen fiber bundles and deposits of proteoglycans in the matrix, whereas type 3 showed normal sclera. Subscleral sclerectomy was effective for types 1 and 2, inducing postoperative resolution of the subretinal fluid. However, type 3 eyes were not helped by this technique. CONCLUSIONS: Primary uveal effusion syndrome is caused by abnormalities of the sclera and increased resistance to transscleral fluid outflow as subscleral sclerectomy is an effective treatment in types 1 and 2 only, correct preoperative classification is essential for early surgical management.
Dr. M. Uyama, Department of Ophthalmology, Kansai Medical University, Moriguchi, Osaka, Japan
Classification:
9.3.10 Other (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
9.4.2 Glaucomas associated with disorders of the cornea, conjunctiva, sclera (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
