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PURPOSE: To investigate the accuracy of measuring intraocular pressure over a silicone hydrogel contact lens using Goldmann applanation tonometry in eyes with glaucoma. METHODS: This was a prospective, randomized study and enrolled 28 patients (28 right eyes) with primary open angle glaucoma. Intraocular pressure was taken with and without a silicone hydrogel contact lens (-0.50 D), in situ (using Goldmann applanation tonometry), in a randomized order of measurements. Statistical analysis was performed using paired t-test and Bland-Altman plot. RESULTS: The mean difference (± standard deviation) found between intraocular pressure measurement without (mean 16.7 ± 3.2 mmHg) and with (mean 17.3 ± 3.0 mmHg) contact lens was found to be -0.57 ± 2.3 mmHg (95% confidence interval, -1.5 to 0.3). No significant statistical difference was found between the two groups with paired t-test (p=0.19). The Bland Altman plot showed some evidence of increasing variability of differences between two measures of intraocular pressure, with increasing intraocular pressure. The 95% limits of agreement of the Bland Altman plot were unacceptably large (-5 mmHg to 3.9 mmHg). CONCLUSION: Agreement between Goldmann applanation tonometry with and without contact lenses seems to be poor in patients with glaucoma, especially for high intraocular pressure.
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6.1.1 Devices, techniques (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)