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Abstract #5731 Published in IGR 2-1
Combined exfoliation and pigment dispersion: an overlap syndrome
Mudumbai R; Liebmann JM; Ritch RTransactions of the American Ophthalmological Society 1999; 97:297-314; discussion 314-321
PURPOSE: To describe a series of patients with combined pigment dispersion syndrome (PDS) and exfoliation syndrome (XFS) and to introduce a concept, the overlap syndrome, to aid in assessing multiple risk factors for glaucomatous damage. METHODS: A retrospective review of the records of all patients on the authors' database who carried a diagnosis of both PDS/pigmentary glaucoma (PG) and XFS/exfoliative glaucoma (XFG). RESULTS: The authors identified 26 patients as having both XFS/XFG and PDS/PG. The average age was 64.3±9.8 years and 19 of the 26 were male. All patients had bilateral PDS/PG. Bilateral XFS/XFG was present in nine of 26 patients, and of the 17 patients with unilateral involvement, the left eye was affected in 13. CONCLUSIONS: Both XFS and PDS are common. Middle-aged patients with known PDS/PG should be suspected of having the onset of XFS if one eye escapes intraocular pressure control. Patients presenting with unilateral XFG may also have signs of PDS/PG, often remitted. The authors define an overlap syndrome as the appearance of a new co-morbidity for glaucomatous damage in a patient with a pre-existing risk factor, which then changes the course, and prognosis of the disease. This concept should be particularly useful in dealing with secondary and normal-tension glaucoma.
Dr. R. Mudumbai, Department of Ophthalmology, New York Eye and Ear Infirmary, New York, NY, USA
Classification:
9.4.3.1 Pigmentary glaucoma (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.3 Glaucomas associated with disorders of the iris and ciliary body)
9.4.4.1 Exfoliation syndrome (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.4 Glaucomas associated with disorders of the lens)
