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Abstract #5759 Published in IGR 2-1
Familial amyloid polyneuropathy type I complicated by chronic glaucoma: three cases
Frau E; Lautier-Frau M; Saindelle-Ribeaudeau F; Adams D; Bousquet A; Labetoulle M; Offret HJournal Français d'Ophtalmologie 2000; 23: 217-220
PURPOSE: The authors report three cases of familial amyloid polyneuropathy type I (FAP) with amyloid infiltration of the vitreum and glaucoma. PATIENTS AND METHODS: The authors reviewed the records of three patients, two females and one male, aged 41, 47 and 83 years, respectively. The three patients had familial amyloid polyneuropathy type I with vitreous infiltration and open angle glaucoma. The two women underwent a liver graft four years earlier. Vitrectomy allowed confirmation of the diagnosis in the 83-year-old patient. Two patients underwent trabeculectomy, histological analysis of the iris and the trabeculum was obtained for one patient. RESULTS: The three patients presented a polyneuropathy, vitreous infiltration and open angle glaucoma. Results of light microscopy of the iris and the trabeculum showed amyloid deposits in the iris and the trabecular meshworks. CONCLUSIONS: Familial amyloid polyneuropathy is a hereditary disease which may have a wide range of ocular manifestations. Glaucoma is among the most serious complications of familial amyloid polyneuropathy. LA: French
Dr. E. Frau, Service d'Ophtalmologie, CHU de Bicetre, 78, avenue du General Leclerc, 94270 Le Kremlin Bicetre, France
Classification:
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
