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Abstract #5766 Published in IGR 2-1
Levodopa may improve vision loss in recent-onset, nonarteritic anterior ischemic optic neuropathy
Johnson LN; Guy ME; Krohel GB; Madsen RWOphthalmology 2000; 107:521-526
OBJECTIVES: To study the effect of levodopa in improving visual function in patients treated within 45 days of onset of nonarteritic anterior ischemic optic neuropathy (NAION). DESIGN: A nonrandomized, retrospective, comparative trial. PARTICIPANTS: The study involved 37 patients with NAION of less than 45 days' duration. METHODS: Eighteen patients who had been treated with levodopa were assigned to the case group, and 19 untreated patients were assigned to the control group. Snellen visual acuity converted to logMAR and mean deviation on Humphrey automated perimetry (Program 24-2, Humphrey Instruments, San Leardro, CA) were evaluated at the initial and six-month visits. INTERVENTION: The 18 patients in the case group were administered a capsule of 100 mg levodopa/25 mg carbidopa (Sinemet 25-100) three times daily for three weeks. MAIN OUTCOME MEASURES: The primary outcome measures were changes in visual acuity and visual field at six months from baseline. Improvement in visual acuity was defined as a difference of -0.3 logMAR or less between the six-month and initial visual acuities, whereas worsened visual acuity was a difference of +0.3 logMAR or more. Each 0.3 LogMar represented a doubling of the visual angle, i.e., a change by three lines on the eye chart. Improvement in visual field was defined as a difference in mean deviation of +3.0 dB or more between the six-month and initial visual field tests, whereas worsened visual field was a difference in mean deviation of -3.0 dB or less. RESULTS: The proportions of patients with worsened, unchanged, and improved visual acuity at six months were compared for the levodopa and control groups. There was a significant difference (p=0.012) between the groups. Examination of the proportions showed that a higher proportion of patients who received levodopa had improved visual acuity with a corresponding lower proportion having worsened visual acuity compared with the control patients. Ten of 13 patients (76.9%) in the levodopa group with 20/40 visual acuity or worse at baseline had improved visual acuity at six months, and none of the 18 patients had worsened visual acuity. In contrast, three of ten control patients (30%) with 20/40 visual acuity or worse at baseline had improved visual acuity at six months, and three of 19 control patients (16.3%) had worsened visual acuity. The proportions of patients with worsened, unchanged, and improved visual fields at 6 months were compared for the levodopa and control groups. There was no significant difference between the groups (p=0.25). CONCLUSIONS: Patients treated with levodopa within 45 days of onset of NAION were more likely to experience improvement and less likely to have worsened visual acuity than untreated patients. Levodopa appears to be beneficial in the treatment of recent-onset NAION.
Dr. L.N. Johnson, Neuro-Ophthalmology Unit, Mason Eye Institute, University of Missouri-Columbia, MS 65212, USA JohnsonLN@health.missouri.edu
Classification:
10 Differential diagnosis e.g. anterior and posterior ischemic optic neuropathy