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Abstract #5788 Published in IGR 2-1
Clonidine provides an allergy-free alternative in glaucoma patients with proven allergy to apraclonidine
Geyer O; Schmidt KG; Pianka P; Neudorfer M; Lazar MGraefe's Archive for Clinical and Experimental Ophthalmology 2000; 238: 149-152
PURPOSE: The aim of this study was to determine allergic responses to clonidine hydrochloride 0.25% in glaucoma patients with proven allergic reaction to apraclonidine 0.5%. METHODS: Fifteen consecutive glaucoma patients with allergic reaction to apraclonidine were prospectively challenged with clonidine hydrochloride 0.25% and evaluated for recurrence of allergic reactions and efficacy of treatment. Intraocular pressure (IOP), conjunctival hyperemia, blood pressure and resting pulse rate were determined at baseline and after one, three, six, and 12 months. RESULTS: None of the patients developed ocular allergic reaction during 12 months on clonidine therapy. Blood pressure and pulse rate did not change significantly with clonidine treatment. Clonidine caused a significant reduction of IOP from baseline. In one patient, topical clonidine caused fatigue, dizziness and dry mouth. CONCLUSIONS: Clonidine did not cause allergic reaction in patients with proven allergy to apraclonidine, indicating that there is no cross-reactivity with apraclonidine. Due to the small series, however, it cannot be assumed that allergy will not occur with clonidine 0.25%, given time and a larger number of patients.
Dr. O. Geyer, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, 6 Weizman Street, Tel-Aviv 64239, Israel
Classification:
11.3.3 Apraclonidine, brimonidine (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)