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Abstract #5794 Published in IGR 2-1
The influence of 0.85% RS-timolol and 0.5% S-timolol on intraocular pressure and systemic arterial blood pressure, heart rate, ECG, and expiratory capacity in patients with ocular hypertension and primary open-angle glaucoma
Czechowicz-Janicka K; Staszkiewicz J; Strzalkowska M; Krajewska M; Popiolek B; Christman AKlinika Oczna 1999; 101: 333-337
PURPOSE: Analysis of local and systemic effects of RS-timolol enantiomer and S-timolol in patients with ocular hypertension and glaucoma: evaluation of risk/benefit ratio. MATERIAL AND METHODS: Nineteen patients (38 eyes) receiving 0.85% RS-timolol and ten patients (20 eyes) receiving 0.5% S-timolol were evaluated using a double-blind test. Intraocular pressure, heart rate, systemic arterial blood pressure, ECG and spirometry were recorded before and two hours after drug administration and after seven days of treatment. RESULTS: There were no statistically significant differences between the intraocular pressure-lowering effects of RS-timolol and S-timolol. In patients receiving both medicines, bradycardia was detected two hours after drug administration. Patients receiving RS-timolol showed increased expiratory capacity compared to those receiving S-timolol. There was no detectable influence of either medicine on ECG and systemic arterial blood pressure. CONCLUSIONS: 0.85% RS-timolol and 0.5% S-timolol produced comparable intraocular pressure-lowering effects. 0.85% RS-timolol had a less severe influence on the respiratory system. LA: Polish
Dr. K. Czechowicz-Janicka, Kliniki Okulistyki Centrum Medycznego Ksztalcenia Podyplomowego w Warszawie
Classification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)