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Abstract #5807 Published in IGR 2-1
Latanoprost-induced iris color darkening: a case report with long-term follow-up
Camras CB; Neely DG; Weiss ELJournal of Glaucoma 2000; 9:95-98
PURPOSE: To determine the effect on iris color of discontinuing latanoprost (LP) treatment in a patient with pronounced iris color darkening, and to assess the possible role of sympathetic innervation. METHODS: In a patient demonstrating pronounced iris color darkening in both eyes after treatment with LP for six months, magnified iris color photographs were taken at three- to six-month intervals for five years after discontinuation of LP treatment. Pupillary testing for sympathetic insufficiency was performed with cocaine 10% or hydroxyamphetamine 1%. RESULTS: The iris color did not appreciably change after discontinuing LP. The cocaine-induced increase in pupillary diameter was considerably greater for the control subject than for the patient who demonstrated the LP-induced color change. CONCLUSIONS: Latanoprost-induced iris color darkening does not appreciably change for several years after discontinuing treatment. Some eyes that show LP-induced darkening may have relative ocular sympathetic insufficiency.
Dr. C.B. Camras, Department of Ophthalmology, University of Nebraska Medical Center, Omaha, NB 68198-5540, USA
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
6.8.1 Anterior segment (Part of: 6 Clinical examination methods > 6.8 Photography)
