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Abstract #5811 Published in IGR 2-1
Efficacy of latanoprost as an adjunct to medical therapy for residual angle-closure glaucoma after iridectomy
Hung PT; Hsieh JW; Chen YF; Wei TJournal of Ocular Pharmacology and Therapeutics 2000; 16:43-47
Residual primary angle-closure glaucoma (PACG) after iridectomy is an important issue among Asians, especially the Chinese. In this study, the authors tested the effectiveness of latanoprost as an intraocular pressure (IOP) lowering agent in cases of residual PACG. Twenty-six eyes of 26 PACG patients with persistently elevated IOP after iridectomy, despite treatment with conventional IOP lowering drugs (beta blockers and pilocarpine), were included. Latanoprost 0.005%, one drop daily, was added adjunctively to all eyes. Measurement of IOP at baseline and after the start of treatment with latanoprost indicated a significant IOP reduction. The IOP decreased by about 21% (p < 0.005) during the first three months, and showed a reduction of about 36% at the end of one year. At the one-year follow up, the IOP was well controlled (below 20 mmHg) in all eyes. These findings show that, in combination with beta blockade and pilocarpine, latanoprost can ameliorate residual PACG after iridectomy and could potentially forestall the need for further therapeutic intervention.
Dr. P.T. Hung, Department of Ophthalmology, Taiwan University Hospital, Taipei, Taiwan, ROC portying@ntumcl.mc.ntu.edu
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
