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Abstract #5812 Published in IGR 2-1
A brief review of recent achievements concerning biochemistry and physiology of prostaglandins in the eye
Kahan LI; Dekov AM; Palfalvi M; Imre GOrvosi Hetilap 1999; 140:2685-2689
Two prostaglandin molecules have important physiological and pathophysiological role in the tissues of the eye. Prostaglandin F2α takes part in mediating intraocular pressure, prostaglandin E2 is the mediator of inflammation. In case of increased intraocular pressure, latanoprost, a derivative of prostaglandin F2α, can be applied. Numerous data are available on the favorable intraocular pressure-lowering effect of latanoprost. It can be applied as a single hypotensive or can be combined with eye-drops currently used in glaucoma. It exerts its therapeutic effect by increasing uveoscleral outflow. Inflammation in the eye can be diminished by nonsteroidal anti-inflammatory drugs, similarly to inflammations in other tissues of the organism. The literature on nonsteroidal anti-inflammatory drugs is huge. Molecules of different structures inhibit the synthesis of prostaglandins. Primarily, they are useful anti-inflammatory agents, reduce intraocular pressure in secondary glaucoma, inhibit intraocular miosis, and prevent development of cystoid macula edema. Nonsteroidal anti-inflammatory drugs do not exert their effects on prostaglandins themselves, but inhibit their synthesis. Hence, the simultaneous use of both latanoprost and nonsteroidal anti-inflammatory drugs improves the safety of therapy in patients prone to uveitis. LA: Hungarian
Dr. L.I. Kahan, II. Szemeszeti Klinika, Semmelweis Orvostudomanyi Egyetem, Budapest, Hungary
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
