advertisement
Abstract #5813 Published in IGR 2-1
Additive hypotensive effect of isopropyl unoprostone ophthalmic solution
Kimura T; Ono J; Ishii R; Kitada H; Fujita K; Yamaguchi T; Ookoshi K; Adachi K; Usuha S; Tsuchiya SJapanese Journal of Clinical Ophthalmology 1999; 53:1869-1876
The authors evaluated the additive or replacement effect of isopropyl unoprostone ophthalmic solution in 149 eyes of 75 patients with glaucoma or ocular hypertension. Their ages averaged 66.3 years. Unoprostone instillation replaced prior beta-blockers in 26 eyes (group 1). Unoprostone was added to beta-blockers in 73 eyes (group 2). Unoprostone was added to beta-blockers and pilocarpine in 22 eyes (group 3). Unoprostone was added to beta-blockers, pilocarpine and dipivefrin in 28 eyes (group 4). A significant hypotensive effect was noted in group 2 (p=0.001) and group 4 (p=0.004). In eyes with initial an intraocular pressure of 18 mmHg or over, a hypotensive effect was also noted in group 1 (p=0.001) and group 3 (p=0.015). The added incidence of effective cases by 1 mmHg or more, and of very effective ones by 3 mmHg or more, was 62% for group 1, 73% for group 2, 64% for group 3, and 64% for group 4. Superficial punctate keratopathy due to unoprostone developed in 13 eyes (9%). The instillation had to be discontinued in one eye. These findings show the synergistic hypotensive effect of topical unoprostone and beta-blockers. LA: <#>
Dr. T. Kimura, Department of Ophthalmology, Ueno Eye Clinic, 3-11-2 Higashi-Ueno Taitoku, Tokyo 110-0015, Japan
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)