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Abstract #5815 Published in IGR 2-1
Effect of latanoprost on intraocular pressure in steroid-induced glaucoma
Scherer WJ; Hauber FAJournal of Glaucoma 2000; 9: 179-182
PURPOSE: To study the effect of monotherapy with latanoprost 0.005% on intraocular pressure (IOP) in a prospective nonrandomized clinical trial of patients newly diagnosed with steroid-induced secondary open-angle glaucoma. PATIENTS AND METHODS: Eight patients (16 eyes) with newly diagnosed steroid-associated secondary open-angle glaucoma were prescribed latanoprost 0.005% once a day in each eye. The initial IOP before treatment served as an internal control for each eye. Intraocular pressure was remeasured after one month of monotherapy with latanoprost. Investigators (WJS) were blinded to initial IOP at the time of remeasurement. After discontinuation of steroids, IOP was rechecked. If IOP was stable, latanoprost was discontinued. IOP was rechecked two to four weeks later to confirm an association with steroid use. RESULTS: IOP was significantly decreased after treatment with latanoprost (18.3±2.8 mmHg) compared with initial IOP (25.3±9.1 mmHg). This change represented a 28% decrease in IOP compared with baseline levels. Average IOP after discontinuation of steroids and latanoprost (17.3±1.4 mmHg) did not differ from IOP measured during treatment with latanoprost, but it was significantly less than the initial IOP before treatment. No adverse effects were noted. CONCLUSIONS: Monotherapy with latanoprost is safe and effective in patients with steroid-induced glaucoma. Advantages include lack of systemic side-effects and convenient once-daily dosing.
Dr. W.J. Scherer, Pasco Eye Institute, 5347 Main Street, Suite 100, New Port Richey, FL 34652, USA
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)