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Abstract #5818 Published in IGR 2-1
Efficacy and safety of latanoprost eye drops for glaucoma treatment: a one-year study in Japan
Suzuki M; Mishima HK; Masuda K; Araie M; Kitazawa Y; Azuma IJapanese Journal of Ophthalmology 2000; 44:33-38
PURPOSE: To evaluate the intraocular pressure (IOP)-lowering effect and safety of latanoprost, a prostaglandin analogue, in patients with primary open-angle glaucoma or ocular hypertension. METHODS: One hundred and twenty-four Japanese patients with primary open-angle glaucoma or ocular hypertension were enrolled in this open-labelled study and were treated with 0.005% latanoprost once daily for one year. RESULTS: At all follow-up visits there was a significant (p < 0.001) reduction in IOP compared with the baseline value. After one year, the IOP was reduced by 5.4±2.9 (mean ± SD) mmHg from a baseline value of 23.5±2.2 mmHg. No evidence of an upward drift in the IOP was observed during the treatment period. The most frequently reported adverse ocular events were mild conjunctival hyperemia and iris pigmentation. Very few adverse systemic events were observed. CONCLUSIONS: Latanoprost eye drops showed a marked and stable IOP-lowering effect during the one-year treatment period. Furthermore, latanoprost was well-tolerated and should be a valuable contribution to the management of glaucoma.
Dr. M. Suzuki, Department of Ophthalmology, Hiroshima University School of Medicine, Japan
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
