advertisement
Abstract #5832 Published in IGR 2-1
Neuroprotective effect of N-methyl-D-aspartate receptor antagonists in an experimental glaucoma model in the rat
Gu Z; Yamamoto T; Kawase C; Matsubara M; Kawase K; Sawada A; Kitazawa YNippon Ganka Gakkai Zasshi 2000; 104: 11-16
PURPOSE: To evaluate the neuroprotective effect of memantine and dizocilpine, which are noncompetitive open-channel blockers of the N-methyl-D-aspartate (NMDA) receptor, on glaucomatous optic neuropathy in an experimental glaucoma model in the rat. METHODS: Experimental glaucoma was induced in the right eyes of 30 Wistar albino rats by intracameral injection of India ink followed by laser trabecular photocoagulation four days later. The left eye served as a control. Either memantine, dizocilpine, or phosphate-buffered saline (PBS) was injected intraperitoneally just before trabecular photocoagulation. Five days later, 3% fast blue was injected into both superior colliculi. The eyes were enucleated another three days later, and flat mounts of the retinas were prepared. Labelled ganglion cells were counted in the area 1 mm away from the optic disc. RESULTS: Five days after laser application, no significant intraocular pressure (IOP) change in the right eye was found among the three groups. In eyes treated with memantine or dizocilpine, significantly more ganglion cells were labelled. CONCLUSION: Systemically applied memantine and dizocilpine had a neuroprotective effect against experimental glaucomatous optic neuropathy in the rat. LA: Japanese
Dr. Z. Gu, Department of Ophthalmology, Gifu University School of Medicine, Japan
Classification:
11.8 Neuroprotection (Part of: 11 Medical treatment)
