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1 General aspects (0)   1.1 Epidemiology (4)   1.2 Population genetics (10)   1.3 Pathogenesis (13)   1.4 Quality of life (1)   1.5 Glaucomas as cause of blindness (1)   1.6 Prevention and screening (4) 2 Anatomical structures in glaucoma (1)   2.1 Conjunctiva (1)   2.2 Cornea (0)   2.3 Sclera (0)   2.4 Anterior chamber angle (0)   2.5 Meshwork (10)     2.5.1 Trabecular meshwork (0)     2.5.2 Schlemms canal (0)     2.5.3 Scleral outlet channels (0)   2.6 Aqueous humor dynamics (5)     2.6.1 Production (0)     2.6.2 Outflow (0)       2.6.2.1 Trabecular meshwork (0)       2.6.2.2 Uveoscleral (0)     2.6.3 Compostion (0)   2.7 Episcleral veins and venous pressure (0)   2.8 Iris (0)   2.9 Ciliary body (2)   2.10 Lens (0)   2.11 Vitreous body (0)   2.12 Choroid, peripapillary choroid, peripapillary atrophy (1)   2.13 Retina and retinal nerve fibre layer (11)   2.14 Optic disc (22)   2.15 Optic nerve (1)   2.16 Chiasma and retrochiasmal central nervous system (0)   2.17 Stem cells (0)   2.20 Other (0) 3 Laboratory methods (0)   3.1 Microscopy (0)   3.2 Electron microscopy (3)   3.3 Immunohistochemistry (3)   3.4 Molecular genetics (2)     3.4.1 Linkage studies (0)     3.4.2 Gene studies (0)   3.5 Molecular biology incl. 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(8)

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Abstract #5839 Published in IGR 2-1

Laboratory investigation: A submicron emulsion of HU-211, a synthetic cannabinoid, reduces intraocular pressure in rabbits

Naveh N; Weissman C; Muchtar S; Benita S; Mechoulam R
Graefe's Archive for Clinical and Experimental Ophthalmology 2000; 238: 334-338

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PURPOSE: To study the ocular hypotensive effect of a nonpsychotropic cannabinoid, HU-211 (11-hydroxy-δ⁸-tetra-hydrocannabinol, dimethylheptyl), an N-methyl-D-aspartate (NMDA) agonist, in normotensive rabbits. METHODS: The cannabinoid HU-211, being lipophilic, was incorporated into a stable oil-in-water submicron sterile emulsion, consisting of 0.12% (w/w) HU-211. A single-dose, randomized and double-masked study was designed, using a Digilab 30R pneumotonometer to measure intraocular pressure (IOP) in normotensive rabbits. RESULTS: Application of a single dose of HU-211 ophthalmic preparation resulted in an IOP reduction of 5.3 mmHg (24% of baseline), first evident at 1.5 hours post-application and persisting for over six hours. A small but significant lowering of pressure (12.5% of baseline) occurred in the contralateral eyes of HU-211 treated rabbits, lasting for four hours post-treatment. CONCLUSION: This work demonstrated that HU-211, incorporated into submicron emulsion, caused a six-hour-long reduction in IOP in the treated eye, with a lesser reduction in the contralateral untreated eye.

Dr. N. Naveh, Glaucoma and Pharmacology Laboratory, Goldschleger Eye Research Institute, Sheba Medical Center, Tel Hashomer, 52621, Israel

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Classification:

11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)

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