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Abstract #58732 Published in IGR 16-3
Current concepts in the diagnosis, pathogenesis and management of nonarteritic anterior ischaemic optic neuropathy
Miller NR; Arnold ACEye 2015; 29: 65-79
Nonarteritic anterior ischaemic optic neuropathy (NAION) is the most common acute optic neuropathy in patients over the age of 50 and is the second most common cause of permanent optic nerve-related visual loss in adults after glaucoma. Patients typically present with acute, painless, unilateral loss of vision associated with a variable visual field defect, a relative afferent pupillary defect, a swollen, hyperaemic optic disc, and one or more flame-shaped peripapillary retinal haemorrhages. The pathogenesis of this condition is unknown, but it occurs primarily in patients with structurally small optic discs that have little or no cup and a variety of underlying vascular disorders that may or may not be known at the time of visual loss. There is no consistently beneficial medical or surgical treatment for the condition, but there are now animal models that allow testing of various potential therapies. About 40% of patients experience spontaneous improvement in visual acuity. Patients in whom NAION occurs in one eye have a 15-19% risk of developing a similar event in the opposite eye over the subsequent 5 years.Eye advance online publication, 4 July 2014; doi:10.1038/eye.2014.144.
Department of Ophthalmology, The Wilmer Eye Institute, The Johns Hopkins Hospital, Baltimore, MD, USA.
Full articleClassification:
10 Differential diagnosis e.g. anterior and posterior ischemic optic neuropathy
