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Abstract #5874 Published in IGR 2-1
Simultaneous subconjunctival and subscleral mitomycin-C application in trabeculectomy
El Sayyad F; Belmekki M; Helal M; Khalil M; El-Hamzawey H; Hisham MOphthalmology 2000; 107:298-301,302
OBJECTIVES: To establish the efficacy and safety of simultaneous subconjunctival and subscleral application of mitomycin-C in trabeculectomy. DESIGN: A prospective, randomized study. PARTICIPANTS: Sixty-eight patients (68 eyes) with refractory glaucomas were included in the study. INTERVENTION: Eyes were randomly assigned to receive intraoperative mitomycin-C (0.3 mg/ml) applied under the conjunctival flap (group 1), scleral flap (group 2), or under both flaps (group 3). MAIN OUTCOME MEASURES: Mean intraocular pressure (IOP), postoperative medications, visual acuity, filtering bleb appearance, and complications. RESULTS: There was a significant difference in IOP at six, nine, and 12 months after surgery among the three groups (p=0.021, 0.026, and 0.033, respectively ANOVA). At 12 months, the mean IOP in group 3 was 9.8±3.7 mmHg compared with 13.4±5.5 mmHg in group 2. (p=0.015) and 12.4±4.4 mmHg in group 1 (p=0.039). Success rate (21 mmHg or less), number of antiglaucoma medications, and complications showed no statistical significant difference between the three groups at each postoperative visit. CONCLUSION: Mitomycin-C applied under the scleral flap may have an additional beneficial effect when combined with simultaneous subconjunctival exposure.
Dr. F. El Sayyad, El-Maghraby Eye Hospital, Jeddah, Saudi Arabia
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)