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Abstract #58871 Published in IGR 16-3

Morphological and morphometric changes in rat optic nerve microvessels in a glaucoma experimental model

Moreno M; Ríos MC; Alba C; Díaz F; Villena A; Figueroa-Ortiz LC; García-Campos J
Archivos de la Sociedad Española de Oftalmologia 2014; 89: 471-476

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AIM: To study the morphological and morphometric changes produced in the capillaries of the optic nerve (ON) head and initial portion after the experimental increase in intraocular pressure (IOP). MATERIAL AND METHODS: Wistar rats underwent cauterization of three episcleral veins, which produced an immediate increase in the IOP, and was maintained for 3 months. Sagittal sections of the eyeball were studied with immunohistochemical techniques, using a primary antibody to GLUT-1. The GLUT-1 positive capillaries were counted, and measurements were made of the area, perimeter and mean diameter. RESULTS: Microscopic examination of sections of the ON of control rats revealed a lower density and larger caliber of capillaries in the prelaminar region as compared with the other regions of the ON (P<.05). Comparison between the control and the experimental groups showed a reduction in capillary density (except in the prelaminar region) and a smaller size in all the areas of the ON studied, but less evident in the initial portion (P<.05). CONCLUSIONS: The increase in IOP was associated with significant qualitative and quantitative changes in the capillaries of the laminar and poslaminar regions of the ON head. These changes appear to return towards parameters compatible with normality in the initial portion of the ON, an area where the vascular collapse was less evident. These findings might explain the significant reduction in ocular blood flow seen in patients with primary open-angle glaucoma.

Área de Oftalmología, Facultad de Medicina, Universidad de Málaga, Málaga, España.

Full article

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Classification:

5.1 Rodent (Part of: 5 Experimental glaucoma; animal models)
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
2.15 Optic nerve (Part of: 2 Anatomical structures in glaucoma)

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