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Abstract #5901 Published in IGR 2-1
Comparison of diclofenac and fluorometholone in preventing cystoid macular edema after small incision cataract surgery: a multicentered prospective trial
Miyake K; Masuda K; Shirato S; Oshika T; Eguchi K; Hoshi H; Majima Y; Kimura W; Hayashi FJapanese Journal of Ophthalmology 2000; 44:58-67
PURPOSE: To compare a nonsteroidal topical solution (0.1% diclofenac) to a steroidal topical solution (0.1% fluorometholone) in preventing cystoid macular edema (CME) and disruption of the blood-aqueous barrier. METHODS: A multicentered, prospective clinical trial was performed on eyes undergoing phacoemulsification followed by implantation of a foldable acrylic intraocular lens by the envelope technique. The presence and degree of cystoid macula edema (CME) was determined by fluorescein angiography. Breakdown of the blood-aqueous barrier was determined by laser flare-cell photometry. RESULTS: Five weeks after surgery, CME was present in three of 53 eyes (5.7%) receiving diclofenac and in 29 of 53 eyes (54.7%) receiving fluorometholone. This difference was statistically significant (p < 0.001). The amount of flare in the anterior chamber at three days, and one, two, five, and eight weeks after surgery was also significantly lower (p < 0.01-p < 0.001) in the diclofenac group. The degree of flare at three days, and one, two, five, and eight weeks after surgery was significantly higher in eyes with CME (p < 0.001). CONCLUSIONS: These findings suggest that diclofenac effectively prevents CME following cataract surgery and that CME is closely related to breakdown of the blood-aqueous barrier.
Dr. K. Miyake, Miyake Eye Hospital, Nagoya, Japan
Classification:
12.12.3 Phacoemulsification (Part of: 12 Surgical treatment > 12.12 Cataract extraction)
