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Abstract #5918 Published in IGR 2-1
Effect of Healon and Viscoat on outflow facility in human cadaver eyes
Lane D; Motolko M; Yan DB; Ethier CRJournal of Cataract and Refractive Surgery 2000; 26:277-281
PURPOSE: To compare the acute effects of Healon (sodium hyaluronate) and Viscoat (sodium chondroitin sulfate-sodium hyaluronate) on outflow facility in human cadaver eyes and determine which viscoelastic agent is least likely to cause an intraocular pressure (IOP) spike after cataract surgery. SETTING: The Glaucoma Research Laboratory, University of Toronto, Ontario, Canada. METHODS: In this prospective paired study, 15 pairs of human cadaver eyes were used. Following the construction of a 3.0-mm scleral tunnel, 0.25 ml Healon was injected into the anterior chamber of one eye and 0.25 ml Viscoat was injected into the contralateral eye. The viscoelastic agents were removed from both eyes in a standardized fashion and the scleral tunnels closed. The eyes were then perfused at a constant IOP of 8.0 mmHg, corresponding to 16.0 mmHg in vivo. Outflow facility (μl/minute (min)/mmHg) was recorded every 15 minutes for 24 hours using standard methods. RESULTS: Outflow facility in the Viscoat-treated eyes decreased appreciably for the first three hours, then recovered somewhat after 12 hours; facility in the Healon-treated eyes showed less of an overall decrease. Over the 24 hour perfusion period, mean outflow facility was 0.037±0.015 μl/min/mmHg (SD) in the Viscoat-treated eyes and 0.060±0.012 μl/min/mmHg in the Healon-treated eyes. Healon reduced outflow facility significantly less than Viscoat between 3.25 and 10.50 hours postoperatively (p < 0.05, two-tailed t test). CONCLUSION: Healon reduced outflow facility less than Viscoat between 3.25 and 10.50 hours postoperatively.
Department of Ophthalmology, University of Toronto, Toronto, Canada
Classification:
12.20 Other (Part of: 12 Surgical treatment)
