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Abstract #59253 Published in IGR 16-3
Metabolomics/Proteomics strategies used to identify biomarkers for exfoliation glaucoma
McNally S; O'brien CJJournal of Glaucoma 2014; 23: S51-4
It is currently estimated that 60 to 70 million people worldwide are affected by open-angle glaucoma and the majority of patients who present to clinic have raised intraocular pressure, visual field loss, and cupping of the optic nerve. Although exfoliation glaucoma (XFG) correlates with age, it is the most common cause of secondary open-angle glaucoma in the world and, with elevated intraocular pressure at onset, this disease runs an aggressive clinical course. XFG differs from primary open-angle glaucoma, in that patients have a diminished response to medication, show accelerated rates of disease progression, and therefore have a higher need for surgery. Here we highlight some major findings in the literature, which relate to the search for biomarkers of XFG by metabolomics and proteomics strategies.
*Department of Ophthalmology, Mater Misericordiae University Hospital †UCD School of Medicine and Medical Science, University College Dublin, Dublin, Ireland.
Full articleClassification:
9.4.4.1 Exfoliation syndrome (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.4 Glaucomas associated with disorders of the lens)
3.12 Proteomics (Part of: 3 Laboratory methods)
