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Abstract #59300 Published in IGR 16-3
A cohort study of duplex Doppler examinations of the carotid artery in primary open angle glaucoma
Marmion VJ; Aldoori MI; Woodcock JP; Stephenson JJRSM open 2014; 5: 2054270414527933
OBJECTIVES: To explore the possibility of pathological change in the common carotid artery at the bifurcation and in the internal carotid artery beyond the bifurcation which could contribute to a reduced diastolic pressure as observed in primary open angle glaucoma. DESIGN: Duplex ultrasonic examinations of carotid bifurcations were conducted on 80 patients. Carotid artery defects were allocated into three types: no demonstrable flow defects, internal carotid artery abnormalities and disease in the carotid bulb. SETTING: Bristol Royal Infirmary Vascular Laboratory. PARTICIPANTS: Eighty patients (mean age 69.6 years) providing a total of 160 sides to the analysis. MAIN OUTCOME MEASURES: An estimated central retinal artery pressure, intraocular pressure and field loss were recorded for each side measured. RESULTS: Doppler investigations revealed significant levels of pathological change in the internal carotid distinct from changes at the carotid bulb. The disease revealed in the internal carotid artery was significantly associated with intraocular pressure (p = 0.032), with an effect small to medium in magnitude. The Q2 measure, derived from mean arterial pressure and intraocular pressure, was also substantively associated with disease in the internal carotid artery. Both intraocular pressure and the Q2 measure effectively discriminated between groups, with field loss providing rather less discriminating capability. There was a strong trend towards a higher intraocular pressures and a greater visual field loss with internal carotid artery disease. CONCLUSIONS: Pathological changes in the extra cranial carotid artery in primary open angle glaucoma exceed those in the arteries classified as normal. The presence of disease specifically in the internal carotid artery emphasised the need for a mechanism for the evaluation of the internal carotid apart from the carotid bulb. A basis for clarifying the presence of an ischaemic zone is proposed.
Bristol Eye Hospital, Bristol BS1 2LX, UK.
Full articleClassification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
