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Abstract #59307 Published in IGR 16-3

Genetic covariance between central corneal thickness and anterior chamber volume: a Hungarian twin study

Toth GZ; Racz A; Tarnoki AD; Tarnoki DL; Szekelyhidi Z; Littvay L; Suveges I; Nemeth J; Nagy ZZ
Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies 2014; 17: 397-404

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BACKGROUND: Few, and inconsistent, studies have showed high heritability of some parameters of the anterior segment of the eye; however, no heritability of anterior chamber volume (ACV) has been reported, and no study has been performed to investigate the correlation between the ACV and central corneal thickness (CCT). METHODS: Anterior segment measurements (Pentacam, Oculus) were obtained from 220 eyes of 110 adult Hungarian twins (41 monozygotic and 14 same-sex dizygotic pairs; 80% women; age 48.6 ± 15.5 years) obtained from the Hungarian Twin Registry. RESULTS: Age- and sex-adjusted heritability of ACV was 85% (bootstrapped 95% confidence interval; CI: 69% to 93%), and 88% for CCT (CI: 79% to 95%). Common environmental effects had no influence, and unshared environmental factors were responsible for 12% and 15% of the variance, respectively. The correlation between ACV and CCT was negative and significant (r ph = -0.35, p < .05), and genetic factors accounted for the covariance significantly (0.934; CI: 0.418, 1.061) based on the bivariate Cholesky decomposition model. CONCLUSION: These findings support the high heritability of ACV and central corneal thickness, and a strong genetic covariance between them, which underscores the importance of identification of the specific genetic factors and the family risk-based screening of disorders related to these variables, such as open-angle and also angle closure glaucoma and corneal endothelial alterations.

Department of Ophthalmology,Semmelweis University,Budapest,Hungary.

Full article

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Classification:

2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)
2.4 Anterior chamber angle (Part of: 2 Anatomical structures in glaucoma)
6.8.1 Anterior segment (Part of: 6 Clinical examination methods > 6.8 Photography)

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