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Abstract #5949 Published in IGR 2-2
Genetic studies on primary open angle glaucoma
Szaflik J; Ambroziak AM; Bal J; Gacek MKlinika Oczna 2000; 102: 9-12
Case work on the newest studies on molecular genetics in primary open-angle glaucoma is presented. The molecular genetics of all types of glaucoma have been the subject of investigation over the past few years. As a result, two loci (GLC3A and GLC3B) have been identified for primary congenital glaucoma, one locus (GLC1A) for juvenile primary open-angle glaucoma, and two further loci (GLC1B and GLC1C) for adult-onset primary open-angle glaucoma. The TIGR gene (trabecular meshwork inducible glucocorticoid response protein) localized in GLC1A was described last year for the first time, and thereafter trials on mutations within this gene were conducted successfully. In this paper, studies are reviewed that present the mapping of the first five GLC loci and identification of mutations. LA: Polish
Dr. J. Szaflik, Katedry i Kliniki Okulistyki II Wydzialu Lekarskiego AM w Warszawie, Poland
Classification:
1.2 Population genetics (Part of: 1 General aspects)
