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1 General aspects (0)   1.1 Epidemiology (10)   1.2 Population genetics (1)   1.3 Pathogenesis (9)   1.4 Quality of life (20)   1.5 Glaucomas as cause of blindness (11)   1.6 Prevention and screening (14) 2 Anatomical structures in glaucoma (0)   2.1 Conjunctiva (8)   2.2 Cornea (39)   2.3 Sclera (17)   2.4 Anterior chamber angle (13)   2.5 Meshwork (0)     2.5.1 Trabecular meshwork (16)     2.5.2 Schlemms canal (13)     2.5.3 Scleral outlet channels (2)   2.6 Aqueous humor dynamics (0)     2.6.1 Production (1)     2.6.2 Outflow (1)       2.6.2.1 Trabecular meshwork (7)       2.6.2.2 Uveoscleral (1)     2.6.3 Compostion (7)   2.7 Episcleral veins and venous pressure (0)   2.8 Iris (8)   2.9 Ciliary body (2)   2.10 Lens (2)   2.11 Vitreous body (1)   2.12 Choroid, peripapillary choroid, peripapillary atrophy (9)   2.13 Retina and retinal nerve fibre layer (69)   2.14 Optic disc (37)   2.15 Optic nerve (3)   2.16 Chiasma and retrochiasmal central nervous system (14)   2.17 Stem cells (8)   2.20 Other (0) 3 Laboratory methods (0)   3.1 Microscopy (1)   3.2 Electron microscopy (2)   3.3 Immunohistochemistry (2)   3.4 Molecular genetics (0)     3.4.1 Linkage studies (1)     3.4.2 Gene studies (60)   3.5 Molecular biology incl. 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Abstract #59499 Published in IGR 16-3

The option of neuroprotective therapeutics for glaucoma

Xiong S; Xu X
Chinese Journal of Ophthalmology 2014; 50: 630-633

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Glaucoma is the second common cause of irreversible blindness worldwide associated with a progressive neurodegenerative disease of retinal ganglion cells (RGC). The major hypothetical mechanisms of the apoptosis of RGCs includes deprivation of neurotrophic factors, excitotoxicity mediated by the interaction of glutamate with NMDAR. This article reviewed current development of three kinds of neuroprotective drugs for glaucoma management such as small-molecule therapeutics, recombinant therapeutic proteins and small-molecule bioactive peptides. Particularly, small peptides, which show high target specificity, high potency and low toxicity compared with small molecules, possession of the advantages of low immunogenicity and high cost-effectiveness over recombinant therapeutics, may become most important choice for neuroprotection against glaucoma of next generation.

Department of Ophthalmology, Shanghai Jiaotong University Affiliated First People's Hospital, Shanghai 200080, China.

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Classification:

11.8 Neuroprotection (Part of: 11 Medical treatment)

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