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Abstract #59562 Published in IGR 16-3
Diagnostic ability of macular nerve fiber layer thickness using a new segmentation software in glaucoma suspects
Martinez-de-la-Casa JM; Cifuentes-Canorea P; Berrozpe-Villabona C; Sastre M; Polo V; Moreno-Montañes J; Garcia-Feijoo JInvestigative Ophthalmology and Visual Science 2014; 0:
PURPOSE: To assess the capacity of internal retinal layer thickness measurements made at the macula using new spectral domain OCT software (Spectralis OCT, Heidelberg Engineering) to distinguish between healthy subjects and those with suspected glaucoma. The diagnostic performance of such measurements was also compared with that of conventional peripapillary retinal nerve fiber layer (RNFL) thickness measurements. METHODS: The study included 38 subjects with suspected glaucoma and 38 age-matched healthy subjects. In one randomly selected eye of each participant, thickness measurements at the level of the macula were made of the nerve fiber layer (mRNFL), the ganglion cell layer (GCL) and the ganglion cell complex (GCC, ganglion cell layer + internal plexiform layer) through automated OCT segmentation. Peripapillary RNFL thickness (pRNFL) was also determined using the conventional scan. RESULTS: As the only variable showing inter-group variation, mRNFL in the glaucoma suspects was significantly thinner in the quadrants inner inferior (p=0.003), inner temporal (p=0.010) and outer inferior (p=0.017). The variable best able to discriminate between the two groups was inner inferior mRNFL thickness, as indicated by an area below the ROC curve of 0.742. CONCLUSION: Macular RNFL thickness measurements showed an improved diagnostic capacity over the other variables examined to distinguish between healthy subjects and glaucoma suspects.
OPHTHALMOLOGY, HOSPITAL CLINICO UNIVERSITARIO SAN CARLOS, Profesor Martin Lagos sn, Madrid, Madrid, 28040, Spain jmmartinezcasa@gmail.com.
Full articleClassification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)
