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Abstract #59582 Published in IGR 16-3

Effect of intraocular pressure control on central corneal thickness, horizontal corneal diameter, and axial length in primary congenital glaucoma

Cronemberger S; Calixto N; Avellar Milhomens TG; Gama PO; Milhomens EG; Rolim H; Mendonça SC
Journal of AAPOS 2014; 18: 433-436

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PURPOSE: To assess the effect of intraocular pressure (IOP) control on central corneal thickness (CCT), horizontal corneal diameter (HCD), and axial length (AL) in primary congenital glaucoma (PCG). METHODS: The medical records of children under 10 years of age surgically treated for PCG from 2003 to 2012 were retrospectively reviewed to identify patients with IOP of ≤12 mm Hg with a minimum of 6 months' follow-up. Pre- and post-treatment IOP, CCT, HCD, and AL values were correlated and compared with those of healthy age-matched controls. RESULTS: A total of 131 controls and 20 patients (12 bilateral; 8 unilateral) were included. Mean follow-up was 32.4 months. In 24 eyes IOP was controlled by 1 trabeculotomy, with 6 eyes requiring antiglaucoma medication; in 5 eyes, by 2 trabeculotomies, without medication; and in 3 eyes, by 2 trabeculotomies plus 1 with mitomycin-C and 2 eyes requiring antiglaucomatous medication. The mean IOP was 15.69 ± 5.31 mm Hg preoperatively and 6.16 ± 2.42 mm Hg at final follow-up. Mean pre- and postoperative CCT values were, respectively, 614.38 ± 89.41 μm and 548.56 ± 63.12 μm; HCD, 13.45 ± 1.00 mm and 13.98 ± 1.01 mm, respectively; AL, 24.57 ± 2.71 mm and 25.37 ± 2.66 mm, respectively. All differences were statistically significant (P ≤ 0.002). In 40% of patients, post-treatment CCT values were comparable to those of controls; in 6.2%, HCD measurements; and in 26%, AL measurements. Pre- and post-treatment measurements were positively correlated (P ≤ 0.009). CONCLUSIONS: Controlling IOP had a positive effect on the CCT, HCD, and AL in patients with congenital glaucoma.

Department of Ophthalmology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address: secronem@gmail.com.

Full article

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Classification:

9.1.1 Congenital glaucoma, Buphthalmos (Part of: 9 Clinical forms of glaucomas > 9.1 Developmental glaucomas)
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)

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