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Abstract #59663 Published in IGR 16-4
Presence of an optic disc notch and glaucoma
Healey PR; Mitchell PJournal of Glaucoma 2015; 24: 262-266
PURPOSE: To assess the prevalence and associations of a notch in the optic disc neural rim. METHODS: Stereo-photographs from the Blue Mountains Eye Study were graded for the presence of a notch (defined as focal reduction in neural rim width associated with a change in the curvature of the rim for no greater than 4 clock hours). RESULTS: A notch was found in at least 1 eye of 205 participants (5.7%), and was bilateral in 51 (1.4%). Notch prevalence increased with age from 2.48% in participants aged <60 years, to 4.1% for ages 60 to 69 years, 7.98% for ages 70 to 79 years and 15.3% for ages 80 years or older. No sex differences were found. Notches were more frequent in eyes with myopia (odds ratio, OR, 1.98, 95% confidence interval, CI, 1.31-2.98) or beta-peripapillary atrophy (OR 2.20, CI 1.52-3.22). No associations were found with intraocular pressure, optic disc hemorrhage, or migraine history. After adjusting for other risk factors, a neural rim notch was strongly associated with glaucoma diagnosis (OR 21.2, CI 8.8-50.8). The sensitivity and specificity for glaucoma with visual field loss of finding a notch in either eye was 90.3% and 96.8%, respectively. The positive predictive value of a notch was 45.4% and negative predictive value 99.7%. CONCLUSIONS: A notch in the neural rim is a relatively infrequent sign in normal eyes but is very frequent in glaucoma. This sign has both good sensitivity and a positive predictive value for glaucoma.
Centre for Vision Research, Westmead Millennium Institute, University of Sydney, Australia.
Full articleClassification:
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
6.8.2 Posterior segment (Part of: 6 Clinical examination methods > 6.8 Photography)
