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Abstract #60092 Published in IGR 16-4
The Interaction of Nepafenac and Prostaglandin Analogs in Primary Open-angle Glaucoma Patients
Ozyol P; Ozyol E; Erdoğan BDJournal of Glaucoma 2016; 25: e145-e149
PURPOSE: To investigate the effect of nepafenac on intraocular pressure (IOP) in primary open-angle glaucoma (POAG) patients treated with prostaglandin (PG) analogs. MATERIALS AND METHODS: This prospective clinical study included 35 patients who had been receiving latanoprost (n=12), travoprost (n=12), or bimatoprost (n=11) for POAG. Nepafenac 0.1% and placebo drops were administered to the right and left eyes of patients, respectively, 3 times a day for 7 days. IOP measurements were taken at 9:00 AM, 12:00 PM, and 4:00 PM at baseline and all consecutive visits. The visits were scheduled on days 1 and 7 during treatment and 1 and 7 days after discontinuation of the treatment. RESULTS: The mean age of the patients was 60.28±7.51 years (range, 48 to 75 y). The baseline IOP was similar in the nepafenac and placebo groups (15.33±1.45 vs. 15.41±1.41, respectively, P>0.05). The decrease in the mean IOP was significant in the nepafenac group compared with the placebo group throughout the treatment period (P<0.001). After the discontinuation of nepafenac treatment, the mean IOP became similar with the placebo group from the first day (P>0.05). The change in mean IOP was not significant between the PG subgroups during treatment and discontinuation periods (P=0.712). CONCLUSIONS: Nepafenac potentiates the IOP-lowering effects of 3 different PG analogs in POAG patients.
*Department of Ophthalmology, Muğla Sitki Koçman University Faculty of Medicine, Muğla †Department of Biostatistics, Faculty of Medicine, Ankara University, Ankara, Turkey.
Full articleClassification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
11.15 Other drugs in relation to glaucoma (Part of: 11 Medical treatment)
6.1.3 Factors affecting IOP (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
