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Abstract #60119 Published in IGR 16-4
Patterns of functional vision loss in glaucoma determined with archetypal analysis
Elze T; Pasquale LR; Shen LQ; Chen TC; Wiggs JL; Bex PJJournal of the Royal Society, Interface / the Royal Society 2015; 12:
Glaucoma is an optic neuropathy accompanied by vision loss which can be mapped by visual field (VF) testing revealing characteristic patterns related to the retinal nerve fibre layer anatomy. While detailed knowledge about these patterns is important to understand the anatomic and genetic aspects of glaucoma, current classification schemes are typically predominantly derived qualitatively. Here, we classify glaucomatous vision loss quantitatively by statistically learning prototypical patterns on the convex hull of the data space. In contrast to component-based approaches, this method emphasizes distinct aspects of the data and provides patterns that are easier to interpret for clinicians. Based on 13 231 reliable Humphrey VFs from a large clinical glaucoma practice, we identify an optimal solution with 17 glaucomatous vision loss prototypes which fit well with previously described qualitative patterns from a large clinical study. We illustrate relations of our patterns to retinal structure by a previously developed mathematical model. In contrast to the qualitative clinical approaches, our results can serve as a framework to quantify the various subtypes of glaucomatous visual field loss.
Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA Max Planck Institute for Mathematics in the Sciences, Leipzig, Germany tobias_elze@meei.harvard.edu.
Full articleClassification:
6.6.2 Automated (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)