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pharmacoeconomics (8) 15 Miscellaneous (24)

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Abstract #60403 Published in IGR 16-4

Transcriptome of the human retina, retinal pigmented epithelium and choroid

Tian L; Kazmierkiewicz KL; Bowman AS; Li M; Curcio CA; Stambolian DE
Genomics 2015; 105: 253-264

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The retina and its adjacent supporting tissues - retinal pigmented epithelium (RPE) and choroid - are critical structures in human eyes required for normal visual perception. Abnormal changes in these layers have been implicated in diseases such as age-related macular degeneration and glaucoma. With the advent of high-throughput methods, such as serial analysis of gene expression, cDNA microarray, and RNA sequencing, there is unprecedented opportunity to facilitate our understanding of the normal retina, RPE, and choroid. This information can be used to identify dysfunction in age-related macular degeneration and glaucoma. In this review, we describe the current status in our understanding of these transcriptomes through the use of high-throughput techniques.

Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pa 19104, USA. Electronic address: tianl@email.chop.edu.

Full article

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Classification:

3.5 Molecular biology incl. SiRNA (Part of: 3 Laboratory methods)

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