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Abstract #60527 Published in IGR 16-4
Genetic variants associated with different risks for high tension glaucoma and normal tension glaucoma in a Chinese population
Chen Y; Hughes G; Chen X; Qian S; Cao W; Wang L; Wang M; Sun XInvestigative Ophthalmology and Visual Science 2015; 56: 2595-2600
PURPOSE: To investigate the association of genetic factors with primary open angle glaucoma (POAG), including high tension glaucoma (HTG) and normal tension glaucoma (NTG), in a Han Chinese population. METHODS: 1157 POAG cases, including 860 HTG and 297 NTG, and 934 normal controls were recruited. 13 previously reported single nucleotide polymorphisms (SNPs) located at 4 gene regions (TMCO1, CDKN2B-AS1, ATOH7 and SIX1/SIX6) were genotyped. Distributions of allele frequencies were compared between cases and controls as well as in the HTG and NTG subgroups. Intra-ocular pressure (IOP), vertical cup disc ratio (VCDR), central corneal thickness (CCT), axial length (AL) and age at diagnosis were also investigated as quantitative phenotypes with genotypes of these SNPs. RESULTS: SNPs rs4656461 and rs7555523 at TMCO1, rs523096 and rs2157719 at CDKN2B-AS1, as well as rs33912345 and rs10483727 at SIX1/SIX6 showed statistically significant association with POAG. SNPs at ATOH7 did not show statistically significant association with POAG in our dataset. In the subgroup analysis of HTG and NTG, multiple variants at CDKN2B-AS1 and SIX1/SIX6 showed stronger association with NTG than HTG. SNPs rs523096 and rs2157719 at CDKN2B-AS1 as well as rs33912345 and rs10483727 at SIX1/SIX6 were found to be associated with IOP where the minor alleles were associated with an increase in IOP. In contrast, SNPs at TMCO1 showed significant association with HTG only. CONCLUSIONS: Genetic variants in CDKN2B-AS1, SIX1/SIX6, and TMCO1 were associated with POAG in a Han Chinese population. CDKN2B-AS1 and SIX1/SIX6 seem to harbor a tendency toward POAG with lower IOP, while carriers of risk alleles at TMCO1 seem to be predisposed to developing POAG with higher IOP.
Department of Ophthalmology and Vision Science, Shanghai Medical College, Eye and Ear Nose Throat Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Full articleClassification:
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
3.4.2 Gene studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)
