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Abstract #60581 Published in IGR 16-4
Genetic associations in PLEKHA7 and COL11A1 with primary angle closure glaucoma: a meta-analysis
Shuai P; Yu M; Li X; Zhou Y; Liu X; Liu Y; Zhang D; Gong BClinical and Experimental Ophthalmology 2015; 43: 523-530
BACKGROUND: Funding sources: This study was supported in part by grants from the Natural Science Foundation of China (81371048 (B.G.); the Department of Sichuan Provincial Health (130167(B.G.)); the Department of Science and Technology of Sichuan Province, China (2015HH0031 (B.G.). DESIGN: A systematic review and meta-analysis PARTICIPANTS: A total of 25271subjects (4895 PACG patients and 20376 controls) in different ethnicities were tested for PLEKHA7 rs11024102 and COL11A1 rs375384. METHODS: A comprehensive literature search was conducted on studies published up to July 2014. SUMMARY: odds ratios (ORs) and 95% confidence intervals (95% CIs) were analyzed. Publication bias of the included articles was evaluated using funnel plots and Egger's test. MAIN OUTCOME MEASURES: OR for the effects of PLEKHA7 rs11024102 and COL11A1 rs3753841on PACG risk. RESULTS: Four eligible articles were included in this study for meta-analysis. The overall result showed that SNPsrs11024102 and rs3753841were statistically associated with PACG (P<0.001) infixed-effects model. Stratified analyses showed that the association of PLEKHA7 rs11024102 and COL11A1 rs3753841 with PACG was statistically significant in Asian population (including South Indian cohort) (P < 0.001). In Caucasian population, significant association of COL11A1 rs3753841 with PACG was detected (P = 0.004), but PLEKHA7 rs11024102 did not show any association with PACG (P = 0.140). CONCLUSIONS: This meta-analysis suggests that PLEKHA7 rs11024102 is associated with PACG in Asian population and COL11A1 rs3753841 has a genetic association with the development of PACG both in Caucasian and Asian populations.
Sichuan Provincial Key Laboratory for Disease Gene Study, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China; Health Management Center, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Full articleClassification:
9.3.5 Primary angle closure (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
3.4.2 Gene studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)
