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Abstract #60601 Published in IGR 16-4
Evaluation of choroidal thickness, intraocular pressure and serum osmolality after the water drinking test in eyes with primary angle-closure
Nongpiur ME; Foo V; De Leon JM; Baskaran M; Tun TA; Husain R; Perera SA; Aung TInvestigative Ophthalmology and Visual Science 2015; 0:
PURPOSE: To evaluate changes in choroidal thickness (ChT), intraocular pressure (IOP), ocular biometry, and serum osmolality after the water drinking test (WDT) in subjects with previous acute primary angle closure (APAC) and primary angle closure glaucoma (PACG). METHODS: Thirty-eight subjects including 21 APAC and 17 PACG were evaluated. Each subject underwent IOP measurement, A-scan biometry, spectral domain-optical coherence tomography (SDOCT), anterior segment-optical coherence tomography (ASOCT) and osmolality measurements at baseline, 30 and 60 minutes after consuming at least 10ml/kg of water. ChT at the macula was measured from SDOCT images using the 7-line scan protocol.. The fellow-eyes of APAC (FE-APAC) were compared to eyes with PACG. RESULTS: The mean age ±standard deviation of the study subjects was 62.8±8.6 years and 21 (55.3%) were females. At baseline, serum osmolality was significantly lower (p<0.001) in the FE-APAC group, whereas ChT was similar in both the groups (p=0.56). At 30 minutes post-WDT, both groups demonstrated a significant increase in IOP (FE-APAC 3.0 (95% confidence interval, CI 1.52, 4.48)mmHg; PACG 5.06 (95%CI 3.68, 6.26)mmHg, p<0.001 for both) and decrease in serum osmolality (p<0.001 for both), but no significant change in ChT. The magnitude of change in IOP was significantly greater in PACG eyes (p=0.04). After multivariate analysis, a lower mean baseline serum osmolality (β=-0.44, p=0.003) was associated with a greater change in ChT at 30 minutes post-WDT. CONCLUSIONS: The increase in IOP after WDT was higher in PACG eyes compared to FE-APAC; however the latter had lower serum osmolality at baseline. Change in mean ChT following WDT was associated with a lower baseline serum osmolality.
Singapore Eye Research Institute, Singapore, 168751, Singapore.
Full articleClassification:
6.13 Provocative tests (Part of: 6 Clinical examination methods)
2.12 Choroid, peripapillary choroid, peripapillary atrophy (Part of: 2 Anatomical structures in glaucoma)
6.1.3 Factors affecting IOP (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
9.3.5 Primary angle closure (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
