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Abstract #60668 Published in IGR 16-4
Fractal Dimension as a New Tool to Analyze Optic Nerve Head Vasculature in Primary Open Angle Glaucoma
Ciancaglini M; Guerra G; Agnifili L; Mastropasqua R; Fasanella V; Cinelli M; Costagliola C; Ambrosone LIn vivo (Athens, Greece) 2015; 29: 273-279
AIM: To investigate the features of optic nerve head (ONH) microvasculature in primary open angle glaucoma using fractal geometry analysis. PATIENTS AND METHOD: ONH blood flow was analyzed at the level of the lamina cribrosa by means of confocal scanning laser Heidelberg Doppler flowmetry (HRF) in medically-controlled early and advanced glaucoma. Fractal dimension D of vasculature map was calculated using the Box Counting. RESULTS: Our data demonstrated that, in patients with advanced glaucoma, fractal dimension D was significantly lower than in controls, whereas, in the early stage of disease, its value was similar. Fractal dimension D of microcirculation was significantly and negatively correlated with the cup-disk area ratio in both early and advanced glaucoma groups, whereas linear cup-disk ratio of the disk, cup shape measure and nerve fiber layer thickness, where correlated only in advanced stage of the disease. CONCLUSION: These findings demonstrate that fractal dimension D of ONH appeared significantly reduced in advanced glaucoma and correlated with the optic disc damage.
Department of Surgical Sciences, Ophthalmic Clinic, University of L'Aquila, L'Aquila, Italy.
Classification:
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
