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Abstract #60694 Published in IGR 16-4
An energy theory of glaucoma
Li Y; Li D; Ying X; Khaw PT; Raisman GGLIA 2015; 63: 1537-1552
A radial array of fortified astrocytes (FASTs) is the load bearing structure of the rat optic nerve head (ONH). At the retinal end the ONH is suspended on a fluid filled extracellular space occupied by modified pigment cells which generate a glomerular-like formation of villi. We propose that regulation of fluid in and out of this space may contribute to buffering the normal fluctuations of intraocular pressure. The energy requirement for the fluid transfer process is provided by the dense vascularity of the ONH and is reflected in the giant mitochondria of the FASTs. We propose that glaucoma occurs when a maintained rise in pressure overwhelms the capacity of this regulatory system. Under these circumstances the FAST array becomes detached from its anchorage in the surrounding ONH sheath. Progressively driven backwards by the pressure, the FASTs degenerate. We propose that the degeneration of the FASTs is associated with ischemic damage caused by the backward stretching of their blood supply. Retraction of the FAST processes deprives the retinal ganglion cell axons of their energy support, resulting in axotomy. We consider that our previously observed rescue of axons and FASTs by transplantation of olfactory ensheathing cells is due to replacement of this lost energy source. GLIA 2015.
Department of Brain Repair and Rehabilitation, Spinal Research Unit, UCL Institute of Neurology, London, United Kingdom.
Full articleClassification:
1.3 Pathogenesis (Part of: 1 General aspects)
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
